Transcriptional Regulation of Hamster P-glycoprotein
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P-glycoprotein of Chinese Hamster
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P-glycoprtein gene of Chinese hamster shows a single start-site in drug-sensitive cells but multiple start-sites in drug resistant cells. What are the mechanisms underlying the transcriptional regulation of Pgp1 in diffrent cell types? Hope you will find something interesting here.
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TATA-less Multiple Start-site Promoters
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Pgp1 promoter belongs to a class of TATA-less promoters with multiple start-sites. This is a sub class of TATA-less promoters. Many natural promoters are TATA-less promoters.
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MED-1
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Dr. Tan A. Ince from Dr. Kathleen W. Scotto's Lab identified a downstream consensus sequence for TATA-less multiple start-site promoters.
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